| 曾振东，范学政，李明，党伟，胡志卿，易剑波.采用微创血肿清除联合单唾酸神经节苷脂治疗高血压脑出血的临床效果[J].神经损伤功能重建,2020,15(8):443-445 |
| 采用微创血肿清除联合单唾酸神经节苷脂治疗高血压脑出血的临床效果 |
| Clinical Therapeutic Effect of Minimally Invasive Hematoma Removal Combined with SialicAcid Ganglioside on Hypertensive Cerebral Hemorrhage |
| |
| DOI： |
| 中文关键词: 高血压脑出血 微创血肿清除术 单唾酸神经节苷脂 临床效果 神经功能损伤 |
| 英文关键词: hypertensive cerebral hemorrhage minimally invasive hematoma removal sialic acid ganglioside clinical effect, neurological impairment |
| 基金项目: |
|
| 摘要点击次数: 3170 |
| 全文下载次数: 3514 |
| 中文摘要: |
| 目的：观察微创血肿清除术联合单唾酸神经节苷脂治疗高血压脑出血的临床效果。方法：选择高血
压脑出血患者121例进行前瞻性研究，随机将患者分为单穿微创组61例（微创血肿清除术）和联合治疗组
（微创血肿清除术联合单唾酸神经节苷脂静脉注射）60例。治疗14 d后，比较2组治疗前后炎性因子指标：
降钙素原（PCT）、白介素-6（IL-6）、IL-1β和C-反应蛋白（CRP）；氨基酸类神经递质：γ-氨基丁酸（GABA）和谷
氨酸（Glu）；肽类神经递质：神经肽 Y（NPY）和 P 物质（SP）；神经损伤指标：S100B 蛋白、髓鞘碱性蛋白
（MBP）、神经元特异性烯醇化酶（NSE）和胶质纤维酸性蛋白（GFAP）。治疗后4个月，比较2组神经功能缺
损程度评分。结果：治疗 14 d 后，2 组的 PCT、IL-6、IL-1β、CRP、Glu、NPY、SP、S100B 蛋白、MBP、NSE 和
GFAP水平均较同组治疗前明显降低（P＜0.05），且联合治疗组低于单穿微创组（P＜0.05），2组的GABA水
平增高，且联合治疗组高于单穿微创组（P＜0.05）。治疗4个月后，2组患者神经功能缺损程度评分均明显
降低（P＜0.05），且联合治疗组低于单穿微创组（P＜0.05）。结论：微创血肿清除术联合单唾酸神经节苷脂
治疗高血压脑出血的可明显改善患者炎性因子水平、神经递质指标，缓解神经功能损伤，疗效优于单用微
创血肿清除术。 |
| 英文摘要: |
| To analyze the clinical effect of minimally invasive hematoma removal combined with
monostearic ganglioside treatment for hypertensive cerebral hemorrhage. Methods: We selected 121 patients
with hypertensive cerebral hemorrhage for prospective study and randomly divided them into the single-pass
minimally invasive group (61 cases) and combined treatment group (60 cases). Patients in the single-pass minimally invasive group were treated with minimally invasive hematoma removal while patients in the combined
treatment group were treated with minimally invasive hematoma removal combined with monostearic ganglioside. Fourteen days after treatment, the pre- and post-surgery inflammatory factor indicators including the procalcitonin (PCT), interleukin-6 (IL-6), IL-1 β, and C-reactive protein (CRP) were compared between the two groups; the amino acid neurotransmitter indicators γ-aminobutyric acid (GABA) and glutamic acid (Glu), peptide neurotransmitter indicators neuropeptide Y (NPY) and substans P (SP), and nerve injury indicators S100B
protein, myelin basic protein (MBP), neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP)
were also compared. The extent of nerve function defect in both groups was assessed and compared 4 months after treatment. Results: Compared with before treatment, the levels of PCT, IL-6, IL-1β, CRP, Glu, NPY, SP, S100B protein, MBP, NSE, and GFAP in both groups 14 days after treatment were significantly lower (P<0.05),
and the decrease in the combined treatment group was more significant than that in the single-pass minimally invasive group (P<0.05). GABA levels were increased in both groups, and the increase in the combined treatment
group was more significant (P<0.05). Compared with before treatment, the neurological impairment of both
groups 4 months after treatment was significantly reduced (P<0.05), and the neurological impairment of the combined treatment group was lower than that of the single-pass minimally invasive group (P<0.05). Conclusion:
Minimally invasive hematoma removal combined with sialic acid ganglioside can significantly improve the inflammatory factor levels and neurotransmitter indicators and lessen the damage to nerve function in hypertensive cerebral hemorrhage patients. The combined treatment is superior to using minimally invasive surgery
alone. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|