| 李康之，司丽红，凌霞，申博，杨旭.持续性姿势-感知性头晕患者脑功能网络度中心度研究[J].神经损伤功能重建,2020,15(7):377-379 |
| 持续性姿势-感知性头晕患者脑功能网络度中心度研究 |
| Degree Centrality Analysis of Brain Functional Network in Patients with PersistentPostural-Perceptual Dizziness |
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| DOI： |
| 中文关键词: 持续性姿势-感知性头晕 静息态功能核磁 度中心度 楔叶 楔前叶 |
| 英文关键词: persistent postural-perceptual dizziness resting state functional magnetic resonance imaging degree centrality cuneus precuneus |
| 基金项目:航天中心医院科
研基金项目（No.
YN201912） |
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| 摘要点击次数: 2622 |
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| 中文摘要: |
| 目的：应用基于体素的度中心度（DC）方法，探讨持续性姿势-感知性头晕（PPPD）患者脑功能网络的
改变。方法：纳入PPPD患者12例及健康受试者12例，均进行静息态功能核磁成像（fMRI），采用基于体素
的DC方法分析fMRI数据，比较PPPD患者与健康受试者的差异。进一步进行相关分析，探讨DC改变与
PPPD患者临床特征的相关性。结果：与健康受试者相比，PPPD患者右侧楔叶、楔前叶（X=12，Y=－84，Z=
21，k=126，P=0.011, FWE校正）DC 值显著降低。 DC 值与 DHI（r=－0.677，P=0.016）、DHI-F（r=－0.581，P= 0.048）、DHI-E（r=－0.690，P=0.013）均呈负相关。结论：PPPD患者楔叶、楔前叶网络节点属性减弱，可能与
患者的持续性头晕不稳及复杂视觉刺激导致症状加重有关。 |
| 英文摘要: |
| : To analyze the changes in the brain functional network of persistent postural-perceptual
dizziness (PPPD) patients using degree centrality (DC) analysis. Methods: Total 12 PPPD patients and 12
healthy subjects were enrolled for this study and were performed resting-state fMRI scans. The fMRI data were
analyzed using a voxel-based DC method, and the differences between PPPD patients and healthy subjects were
compared. Further correlation analysis was conducted to investigate the correlation between the DC changes and
clinical features in PPPD patients. Results: Compared with that of healthy subjects, the DC value in the right
cuneus and precuneus of PPPD patients was significantly lower (X=12, Y=－84, Z=21, k=126, P=0.011, FWE
corrected). Correlation analysis revealed that the DC value was negatively correlated with DHI (r=－0.677, P= 0.016), DHI-F (r=－0.581, P=0.048), and DHI-E (r=－0.690, P=0.013) scores. Conclusion: In patients with
PPPD, the network hub properties of the cuneus and precuneus are weakened, and this may be related to the
patient's persistent dizziness and instability and worsening symptoms due to complex visual stimulation. |
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