| 何婷玉，王惠玲，荣蓓，武止戈.围绝经期抑郁症患者的血清甲状腺激素水平研究[J].神经损伤功能重建,2020,15(6):329-331 |
| 围绝经期抑郁症患者的血清甲状腺激素水平研究 |
| Serum Thyroid Hormone Levels in Patients with Perimenopause Depression |
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| DOI： |
| 中文关键词: 围绝经期抑郁症 甲状腺激素 |
| 英文关键词: perimenopause depression thyroid hormone |
| 基金项目: |
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| 中文摘要: |
| 目的：探索围绝经期抑郁症患者的血清甲状腺激素水平的变化及临床意义。方法：围绝经期抑郁症
患者32例（抑郁组）、围绝经期抑郁焦虑共病患者30例（共病组）、围绝经期焦虑症患者50例（焦虑组）、围绝
经期健康人85例（对照组）纳入研究；使用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评估
各研究对象的临床症状。进一步根据入组时是否有消极观念、自杀行为的情况及HAMD评分第3项有关自
杀内容评分≥2分，将抑郁组、共病组患者再分为消极亚组和非消极亚组。检测并比较所有研究对象游离三
碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和促甲状腺激素（TSH）的水平。结果：各组的甲状腺激素水平
均在正常范围内。抑郁组和共病组的FT3水平均明显低于焦虑组（P＜0.05）和对照组（P＜0.01）；其他各组
间FT3水平差异无统计学意义（P＞0.05）；4组间的FT4、TSH水平差异无统计学意义（P＞0.05）。抑郁组和
共病组的消极亚组HAMD总分均显著大于非亚消极组（P＜0.01），而HAMA总分差异无统计学意义（P＞ 0.05）。抑郁组和共病组的消极亚组和非消极亚组的血清FT3、FT4、TSH水平均未见明显差异（P＞0.05）。
抑郁组和共病组的消极亚组中，FT3水平与HAMD总分呈负相关（P＜0.05）。结论：围绝经期抑郁症女性血
清FT3水平相对下降，在具有自杀意念、行为等消极风险的人群中，FT3水平的下降与抑郁严重程度存在一
定相关性。 |
| 英文摘要: |
| To explore the changes of serum levels of thyroid hormones and their clinical significance in patients with perimenopause depression. Methods: Thirty-two patients with perimenopause depression
(depression group), 30 perimenopausal patients with comorbidity of anxiety and depression (comorbidity group),
50 perimenopausal patients with anxiety disorders (anxiety group), and 85 perimenopausal normal controls (control group) were screened. The Hamilton Depression scale (HAMD) and Hamilton Anxiety Scale (HAMA) were
used to assess the clinical symptoms of each subject. According to the presence or absence of negative perceptions, suicidal behaviors, and a ≥2 score on the third (suicide) item of the HAMD, the depression group and comorbidity group were further divided into the negative and non-negative subgroups. The serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) in fasting blood samples
were measured and compared in all subjects. Results: The serum thyroid hormones levels in all groups were
within the normal biological reference intervals. The serum levels of FT3 in the depression group and comorbidity group were significantly lower than those in the anxiety group (P<0.05) and control group (P<0.01); there was
no significant difference in the serum levels of FT3 between the other groups (P>0.05). No significant difference
in the serum levels of FT4 and TSH were found among the four groups (P>0.05). Compared to the non-negative
subgroup, the negative subgroup in the depression group and comorbidity group showed a greater HAMD total
score (P<0.01); there was no significant difference in the HAMA total score between the subgroups (P>0.05).
There was no significant difference in serum FT3, FT4, and TSH levels between the negative and non-negative
subgroups of the depression group and comorbidity group (P>0.05). In the negative subgroup of the depression
group and comorbidity group, the serum FT3 level displayed a negative correlation with the HAMD total score
(P<0.05). Conclusion: The serum levels of FT3 are decreased in perimenopausal women with depression, and
in those with a risk of suicidal ideation and behavior, the decrease in FT3 level may be related to the severity of
depression. |
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