| 宣天福，吴媚，张晶晶.神经血管单元对脑血管新生的调控研究进展[J].神经损伤功能重建,2024,(知网首发): |
| 神经血管单元对脑血管新生的调控研究进展 |
| Research Progress on the Regulation of Cerebral Angiogenesis by the Neurovascular Unit |
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| DOI： |
| 中文关键词: 脑血管新生 神经元 星形胶质细胞 周细胞 小胶质细胞 |
| 英文关键词: cerebral angiogenesis neuron astrocyte pericyte microglia |
| 基金项目:国家自然科学基金-
优秀青年科学基金
项目（血脑屏障的
发育与稳态维持，
No. 32222028）；湛
江市科技发展专项
资金-重点实验室
建设专题（斑马鱼
发育与疾病动物模
型重点实验室建设
项目，No. 2022A01
231） |
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| 中文摘要: |
| 脑血管新生是脑脉管系统发育的重要生理过程，也是脑血管损伤后的主要修复方式。脑血管新生异
常可能导致脑肿瘤生长和动静脉畸形等病理状态。神经血管单元是由神经元、神经胶质细胞和周细胞等
组成的大脑最小功能单位，参与维持大脑微环境的稳态。神经血管单元对脑血管新生具有重要的调控作
用。本文主要综述神经血管单元中各种细胞组分，如神经元、星形胶质细胞、小胶质细胞、周细胞和平滑肌
细胞，在脑血管新生过程中的调控作用及机制，旨在为脑血管新生相关疾病的研究及临床治疗提供参考。 |
| 英文摘要: |
| Cerebral angiogenesis is an important physiological process for the development of the
cerebrovascular system and the primary mechanism of revascularization following cerebrovascular damage.
Abnormal cerebral angiogenesis may lead to several diseases, such as brain tumor growth and arteriovenous
malformations. Neurovascular unit, the smallest functional unit of the brain, consists of neurons, glial cells,
pericytes, etc., and is involved in maintaining homeostasis of the brain microenvironment. The neurovascular
unit has crucial roles in cerebral angiogenesis. In this paper, we review the regulatory roles and mechanisms of
various cellular components of the neurovascular unit (neurons, astrocytes, microglia, pericytes, and smooth
muscle cells) in cerebral angiogenesis, which will provide an important reference for the research and clinical
treatment of cerebrovascular-related disorders. |
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