| 魏瑞晗
，饶家声,
，赵璨,
，赵文
，杨朝阳,
，李晓光,，.恒河猴脊髓半切损伤后下肢节段功能表现的研究[J].神经损伤功能重建,2019,14(12):608-610 |
| 恒河猴脊髓半切损伤后下肢节段功能表现的研究 |
| Impairment of Motor Performance of Hindlimb Segments after Spinal Cord Hemi-Sectionin Rhesus Monkeys |
| |
| DOI： |
| 中文关键词: 脊髓损伤 恒河猴 肢体节段 仰角 |
| 英文关键词: spinal cord injury rhesus monkey hindlimb segment elevation angle |
| 基金项目:国 家 重 点 研 发 计 划
（No. 2017YFC110400
1，2017YFC1104002）；
国 家 自 然 科 学 基 金
（No.31730030，31650
001，31670988，31320
103903，31771053，31
970970，31900980）；
北京市科技计划（No.
Z181100001818007）；
北京市自然科学基金
青年项目
北京市教育委员会科
技计划重点项目（No.
KZ201810025030）；
中国博士后科学基金
面上资助（No.2018M
640046）；
中央高校基本科研业
务 费 专 项 资 金 资 助
（No.YWF-19-BJ-J-28
2） |
|
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| 全文下载次数: 3839 |
| 中文摘要: |
| 目的：研究脊髓半切损伤后恒河猴下肢各节段运动功能的变化。方法：成年雌性恒河猴3只，行
胸髓T7-9节段半切手术；于术前、术后6及12周分别记录猴的下肢节段仰角变化；计算并分析不同时间
点猴下肢节段仰角幅值及节段间仰角相关性。结果：术后6及12周，大腿节段仰角幅值均低于术前
（P＜0.001），且术后 6 周与 12 周差异无统计学意义（P＞0.05）；术后小腿和足部仰角幅值均低于术前
（P＜0.01），但术后12周高于术后6周（均P＜0.01或P＜0.001）。术后6及12周，大腿仰角与小腿仰角
间相关系数均值均低于术前；术后6周，小腿仰角与足仰角间相关系数均值低于术前（P＜0.001），术后
12周，小腿仰角与足仰角间相关系数均值增加，但仍低于术前（P＜0.01）；术后6及12周，大腿仰角与小
腿仰角间相关系数和小腿仰角与足仰角间相关系数均值的差异无统计学意义（P＞0.05）。结论：SCI
后，下肢各节段均有严重运动障碍，经自发恢复，小腿足部节段活动范围及协调性有部分改善，这可能
揭示了受损脊髓神经传导的可塑性恢复。 |
| 英文摘要: |
| To study the changes in motor function of hindlimb segments after spinal cord
hemi-section in rhesus monkeys. Methods: Three adult female rhesus monkeys received a hemi-section in
the thoracic spinal cord at T7-T9. Hindlimb kinematic recordings were made prior to and at 6 and 12 weeks
after the procedure. The amplitude of elevation angles of hindlimb segments and the correlation between
elevation angles in different time points was calculated and analyzed. Results: At both 6 and 12 weeks
after surgery, the thigh segment elevation angle was smaller than that before surgery (P<0.001), and there
was no significant difference between elevation angles at 6 and 12 weeks after surgery (P>0.05). After
surgery, shank and foot elevation angles were both smaller than those before surgery (P<0.01), but elevation
angles at 12 weeks were greater than those at 6 weeks (P<0.01 or P<0.001). At 6 weeks and 12 weeks after
surgery, the correlation coefficient between thigh and shank elevation angles was lower than that before
surgery. At 6 weeks after surgery, the correlation coefficient between shank and foot elevation angles was
lower than that before surgery (P<0.001); 12 weeks after surgery, there was an increase in the correlation
coefficient between shank and foot elevation angles, but this value remained lower than that before surgery
(P<0.01). At 6 weeks and 12 weeks after surgery, there was no significant difference between the correlation
coefficient between thigh and shank elevation angles and that between shank and foot elevation angles (P> 0.05). Conclusion: All hindlimb segments showed severe motor dysfunction after spinal cord injury and
recovered spontaneously after a period of time; this may shed light on the plasticity of recovery of nerve
conduction in the injured spinal cord. |
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