文章摘要
崔琴 ，湛彦强 ，胡丹 ，王翠芳 ，张琦 ，徐露 ，姚涛.非空腹甘油三酯与急性脑梗死预后的关系[J].神经损伤功能重建,2019,14(11):547-550
非空腹甘油三酯与急性脑梗死预后的关系
Correlation between Non-Fasting Triglyceride Level and Prognosis of Acute CerebralInfarction
  
DOI：
中文关键词: 急性脑梗死  非空腹甘油三酯  预后
英文关键词: acute cerebral infarction  non-fasting triglyceride  prognosis
基金项目:国家自然科学基金青 年基金（No.8140105 1）；武汉大学人民医 院引导基金（No.RM YD2018M09）
作者单位
崔琴a ，湛彦强b ，胡丹b ，王翠芳a ，张琦a ，徐露a ，姚涛a 湖北省人民医院 a. 东院神经内Ⅰ科， b. 神经内Ⅰ科 
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中文摘要:
      目的：探讨血浆非空腹甘油三酯水平（TG）对急性脑梗死患者预后的影响。方法：回顾性收集急性 脑梗死患者446例，记录其入院时血压、血糖、美国国立卫生研究院卒中量表（NIHSS）评分、血浆甘油三 脂（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及高密度脂蛋白胆固醇（HDL-C）水平。改良 Rankin 量表（mRS）评估患者 3 月时的预后，并对影响患者预后的危险因素进行多因素 Logistic回归分 析。结果：与预后良好组相比，预后不良组的患者年龄、BMI更大，基线NHISS评分、基线空腹血糖更高， 冠心病、心房颤动患病率更高，非空腹TG水平较低（P<0.05）。单因素回归分析显示，年龄、BMI、吸烟、冠 心病、房颤、基线空腹血糖、基线NIHSS评分和血浆非空腹TG水平是影响脑梗死预后的因素（P<0.05）。 多因素回归分析显示，高非空腹TG水平（OR=0.548，95%CI 0.372~0.808，P=0.002）是脑梗死良好结局的 预测因子。非空腹 TG 水平预测患者良好结局的 ROC 曲线下面积为 0.669（95% CI 0.618~0.702，P= 0.000），其预测临界值为非空腹TG 1.455 mmol/L时，敏感度为67.9%，特异度为61.8%。结论：急性脑梗 死患者发病时非空腹TG水平是90 d良好结局的独立预测因素。
英文摘要:
      To investigate the effect of plasma non-fasting triglyceride (TG) levels on the prognosis of patients with acute cerebral infarction. Methods: A total of 446 patients with acute cerebral infarction were retrospectively enrolled. The blood pressure, blood glucose, National Institutes of Health Stroke Scale (NIHSS) score, and plasma triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) levels at time of admission were recorded. The prognosis of the patients was evaluated by modified Rankin Scale (mRS) at 3 months after onset, and univariate and multivariate Logistic regression were used to analyze the risk factors that influence prognosis. Results: Compared with the good prognosis group, the poor prognosis group had a higher age, BMI, NHISS score, fasting blood sugar, and prevalence of coronary heart disease (CHD) and atrial fibrillation (AF) and a lower level of non-fasting TG (P<0.05). Univariate regression analysis showed that age, BMI, history of smoking, CHD, AF, fasting blood glucose, NIHSS score, and plasma non-fasting TG were the prognostic factors of acute cerebral infarction (P<0.05). Multivariate Logistic regression analysis showed that a higher non-fasting TG level (OR=0.548, 95% CI 0.372~0.808, P=0.002) was a predictor of a good outcome in acute cerebral infarction. The area under the ROC curve of the non-fasting TG level was 0.669 (95%CI 0.618~0.702，P=0.000), and the sensitivity and specificity were 67.9% and 38.2% respectively when the non-fasting TG level was 1.455 mmol/L. Conclusion: Non-fasting TG is an independent predictor of a good outcome at 90 days after the onset of acute cerebral infarction.
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