文章摘要
王珲 ，谭向红 ，陈艳香 ，唐荣华.左旋多巴联用普拉克索治疗原发性不宁腿综合征的疗效观察[J].神经损伤功能重建,2019,14(9):441-443
左旋多巴联用普拉克索治疗原发性不宁腿综合征的疗效观察
Effects of Pramipexole Combined with L-dopa on Patients with Idiopathic Restless LegsSyndrome
  
DOI：
中文关键词: 原发性不宁腿综合征  左旋多巴  普拉克索
英文关键词: restless legs syndrome  L-dopa  pramipexole
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作者单位
王珲1 ，谭向红1 ，陈艳香1 ，唐荣华2 1. 南方医科大学附 属小榄医院神经内 科 2. 华中科技大学同 济医学院附属同济 医院神经内科 
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中文摘要:
      目的：观察左旋多巴联合应用普拉克索对原发性不宁腿综合征（RLS）患者的疗效。方法：中~重度原 发性RLS患者30例，随机分为对照组和联合组各15例，2组均予普拉克索0.25~0.75 mg/d，联合组还予美多 巴62.5～125 mg/d，治疗6周。利用RLS严重程度量表（IRLS）、临床总体印象改善量表（CGI-I）、患者总体印 象量表（PGI）和Epworth嗜睡量表（ESS）评估患者治疗前后的RLS症状严重程度和嗜睡程度，同时记录不良 反应。结果：2 组治疗后 IRLS 评分均低于治疗前(P＜0.05)；联合组治疗后的 IRLS 评分低于对照组(P＜ 0.05)。治疗后，联合组的CGI-I及PGI评估显效率高于普拉克索组 (P＜0.05)。2组治疗后ESS评分均低于 治疗前 (P＜0.05)，2组治疗后的ESS评分差异无统计学意义(P＞0.05)。结论：左旋多巴联合应用普拉克索 对原发性RLS的疗效优于单用普拉克索。
英文摘要:
      To demonstrate the efficacy of pramipexole combined with L-dopa on patients with idiopathic restless legs syndrome (RLS). Methods: Thirty patients with moderate to severe RLS were randomly divided into the control group and combined group with 15 patients in each. During the 6 weeks of treatment, both groups were given Pramipexole (0.25~0.75 mg/d), and the combined group was additionally given Madopar (62.5~125 mg/d). The international RLS scale (IRLS)，patient global impression (PGI) scale, clinical global impressions-improvement (CGI-I) scale, and Epworth sleepiness scale (ESS) were used to evaluate RLS symptom severity and sleepiness before and after treatment; incidence of adverse events was also recorded throughout the trial. Results: IRLS scores decreased after therapy both in both groups (P＜0.05), and the post-treatment IRLS score in the combined group was lower than that in the control group (P＜0.05). After therapy, CGI-I and PGI scores of the combined group were significantly greater than that in the control group (P＜0.05). ESS scores decreased after therapy in both groups (P＜0.05), and there was no statistical difference between the post-treatment ESS scores of the two groups (P＞0.05). Conclusion: The efficacy of pramipexole combined with L-dopa in the treatment of idiopathic RLS is greater than that of pramipexole alone.
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