祝艳莎,李昕昱,李青云,来青伟,胡朋,樊红彬.以癫痫发作为首发症状的自身免疫性脑炎8例
临床分析[J].神经损伤功能重建,2019,14(7):336-341 |
以癫痫发作为首发症状的自身免疫性脑炎8例
临床分析 |
Clinical Analysis of Autoimmune Encephalitis with Seizure as First Symptom: 8 Cases Report |
|
DOI: |
中文关键词: 自身免疫性脑炎 癫痫发作 临床特征 |
英文关键词: autoimmune encephalitis seizure clinical features |
基金项目:江苏省重点实验室
开放研究课题资助
(NO. KF-XY20150
3) |
|
摘要点击次数: 2727 |
全文下载次数: 2750 |
中文摘要: |
目的:分析以癫痫发作为首发症状的自身免疫性脑炎的临床资料。方法:回顾性分析以癫痫发作为首
发症状的自身免疫性脑炎8 例患者的临床表现、实验室检测结果、影像学检查、脑电图特点、治疗结果及随访
记录,并结合文献讨论。结果:8 例患者中,抗NMDAR脑炎5 例,抗GABAR脑炎2 例,抗LGI1 脑炎1 例;男6
例,女2 例;发病年龄18~66 岁,平均50 岁;均以癫痫发作为首发症状,均有反应迟钝、近记忆力下降的症状,
其中出现精神行为异常3 例,言语障碍1 例,顽固性低钠血症1 例;均有≥1 种的癫痫发作形式,脑电图异常6
例;头颅MRI检查异常4 例。结论:对于以癫痫发作为首发症状的自身免疫性脑炎患者,早期免疫治疗及抗
癫痫治疗,对于控制症状、改善预后具有重要意义。 |
英文摘要: |
To analyze the clinical data of autoimmune encephalitis with seizure as the first
symptom. Methods: The clinical manifestations, laboratory test results, imaging examinations,
electro-encephalogram (EEG) characteristics, treatment, and follow-up records of 8 autoimmune encephalitis
cases with seizure as the first symptom were retrospectively reviewed and discussed in combination with
literature. Results: Among the 8 cases, there were 5 cases with anti-NMDAR encephalitis, 2 cases with
anti-GABAR encephalitis, and 1 case with anti-LGI1 encephalitis; there were 6 males and 2 females; the age of
onset ranged from18 to 66 years old, with an average age of 50 years. All the patients experienced seizure as the
first symptom and demonstrated slow response and short-term memory decline. Among them, 3 cases exhibited
abnormal mental behavior, 1 exhibited speech disorder, and 1 exhibited refractory hyponatremia. All displayed
seizure of one or more types. There were 6 cases with abnormal EEG and 4 cases with abnormal MRI.
Conclusion: Early immunotherapy and anti-epileptic treatment are of great significance in controlling
symptoms and improving prognosis for patients with autoimmune encephalitis with epilepsy as the first
symptom. |
查看全文
查看/发表评论 下载PDF阅读器 |
关闭 |