| 来小音汪璐张盼杨雪莲孙家兰胡荣郭卜碧涛李龙宣.脑梗死患者血中IL-6、IL-8 及TNF- α水平与
血液凝固状态的相关性分析[J].神经损伤功能重建,2019,14(6):275-277 |
| 脑梗死患者血中IL-6、IL-8 及TNF- α水平与
血液凝固状态的相关性分析 |
| Correlation between Coagulation and IL-6, IL-8, and TNF-α Levels in Patients with CerebralInfarction |
| |
| DOI： |
| 中文关键词: 血栓弹力图 脑梗死 白介素-6 白介素-8 肿瘤坏死因子-α |
| 英文关键词: thromboelastography cerebral infarction interleukin-6 interleukin-8 tumor necrosis factor-α |
| 基金项目:上海市浦东新区科
技发展基金（No.
PKJ2018-Y07）
上海市卫生系统优
秀人才培养计划项
目
上海市卫生和计划
生育委员会科研基
金
浦东新区卫生和计
划生育委员会学科
带头人培养计划 |
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| 中文摘要: |
| 目的：探讨急性脑梗死患者血中白细胞介素6（IL-6）、IL-8 及肿瘤坏死因子-α（TNF-α）的变化与血液凝
固状态之间的关系。方法：急性脑梗死患者74 例，根据美国国立卫生研究院卒中量表（NIHSS）评分不同分
为轻度卒中组41 例和中重度卒中组33 例，纳入同期住院的非脑梗死患者30 例为对照组。检测血清中IL-6、
IL-8 和TNF-α，血栓弹力图（TEG）检测凝血状态。分析细胞因子与凝血状态之间的关系。结果：脑梗死组患
者血中反应血凝块硬度的G值明显高于对照组（P＜0.05），中重度脑卒中组反应血凝块硬度的G和MA值水
平均较对照组增高（P＜0.05）；脑梗死组IL-6 和TNF-α高于对照组（P＜0.05），中重度卒中组IL-6 和TNF-α明
显高于对照组（P＜0.05）；中重度组IL-8 明显高于轻度卒中组（P＜0.05）；脑卒中患者血中TNF-α的变化与
TEG中的G值呈正相关（r=0.295，P=0.015）。结论：IL-6 及TNF-α参与了脑梗死血液高凝状态的形成；IL-8
与病情严重程度相关；TNF-α与血凝块的硬度相关，可能是促进脑梗死患者血栓形成的重要因素。 |
| 英文摘要: |
| To investigate the relationship between coagulation and the changes in levels of
lnterleukin-6 (IL-6), IL-8, and tumor necrosis factor-α (TNF-α) in patients with acute cerebral infarction.
Methods: We recruited 74 patients with acute cerebral infarction. Patients were divided into the mild stroke
group (n=41) and moderate-to-severe stroke group (n=33) according to severity of symptoms based on the
National Institute of Health stroke scale (NIHSS) score. In addition, 30 patients without cerebral infarction and
hospitalized during the same time as the cerebral infarction group were recruited as the control group.
Coagulation was evaluated by thromboelastography, and serum levels of IL-6, IL-8, and TNF-α were detected by
chemiluminescence analysis. We studied changes in cytokines between the groups and analyzed their relationship
with coagulation. Results: The G-value reflecting clot hardness was higher in the cerebral infarction group than
in the control group (P<0.05), and the increase in G-value and MA was greater in the moderate-to-severe stroke
group compared to the control group (P<0.05). Compared to the IL-6 and TNF-α levels of the control group,
those of the cerebral infarction group were higher (P<0.05) and those of the moderate-to-severe stroke group
were significantly higher (P<0.05). IL-8 level in the moderate-to-severe stroke group was higher than that in the
mild stroke group (P<0.05). Changes in serum TNF-α levels in cerebral infarction patients showed a positive
correlation to G-value in TEG (r=0.295, P=0.015). Conclusion: IL-6 and TNF-α are involved in the coagulation
of blood in patients with cerebral infarction. IL-8 is related to the severity of disease. TNF-α is related to the
hardness of the clot which may be an important factor in promoting thrombosis in patients with cerebral
infarction. |
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