| 田大臣,
，陈旺,
，田茜
，孟凡华
，王贤军.卵圆孔封堵术治疗偏头痛合并右向左分流的
临床研究[J].神经损伤功能重建,2019,14(4):173-175 |
| 卵圆孔封堵术治疗偏头痛合并右向左分流的
临床研究 |
| Clinical Study of Patent Foramen Ovale Transcatheter Closure on Migraine Patients Combinedwith Right-to-left Shunt |
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| DOI： |
| 中文关键词: 卵圆孔未闭 偏头痛 右向左分流 临床研究 封堵术 |
| 英文关键词: patent foramen ovale migraine right-to-left shunt clinical study transcatheter closure |
| 基金项目: |
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| 摘要点击次数: 3678 |
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| 中文摘要: |
| 目的：评价卵圆孔封堵术治疗偏头痛合并右向左分流（RLS）的临床疗效及安全性。方法：偏头痛合并
RLS患者114例随机分为手术组及对照组，各57例；手术组采用卵圆孔封堵术治疗，对照组采用常规药物治
疗。观察治疗后1年2组HIT-6评分与评分差值；术后1月内与1年后并发症发生率；术后24 h与1年后残余
分流及新发梗死灶情况。结果：治疗1年后，手术组HIT-6评分为（49.57±4.58）分，差值为（14.38±3.57）分；对
照组HIT-6评分为（56.85±5.69）分，差值为（8.64±2.24）分，2组差异均有统计学意义（P<0.05）。术后1月内发
生并发症11例（19.30%），1年后并发症均消失。术后24 h大量残余分流患者8例（14.04%），1年后仅1例
（1.92%）存在大量残余分流。治疗1年后，手术组患者7例出现新发梗死灶，对照组17例，2组差异有统计学
意义（P<0.05）。结论：卵圆孔封堵术可有效改善患者偏头疼症状，安全性高，并可降低脑卒中发病风险。 |
| 英文摘要: |
| To evaluate the clinical efficacy and safety of patent foramen ovale (PFO) transcatheter
closure treatment on patients who have migraine with right-to-left shunt (RLS). Methods: One hundred and
fourteen patients with migraine combined with RLS were randomized into operation group (to undergo PFO
transcatheter closure, n=57) or control group (to receive conventional medical therapy, n=57). The
headache-impact-test score (HIT-6) and the reduction to baseline in HIT-6 at one year after treatment were
compared between 2 groups. The incidence rates of complications at one month and one year after treatment, the
residual RLS at 24 h and one year after treatment, and the new onset of cerebral infarction at one year after
treatment were compared. Results: One year after treatment, the HIT-6 grade was (49.57 ± 4.58) and the
difference value was (14.38±3.57) in the operated group, and the values were (56.85±5.69) and (8.64±2.24) in
the control group respectively (P<0.05). There were 11 (19.30%) patients with complications which disappeared
after one year of operation. There were 8 (14.04% ) patients with large residual shunt at 24 h while only 1
(1.92%) patient with large residual shunt after one year of operation. Seven in operation group and 17 in control
group developed new cerebral infarction after one year (P<0.05). Conclusion: PFO closure is a safe and
effective way to treat patients who have migraine with RLS. It can also reduce the risk of stroke |
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