| 韩瑞玲，孙思，汪明，李艳.大动脉粥样硬化型缺血性脑卒中患者SLCO1B1 基因
多态性分布--185 例分析[J].神经损伤功能重建,2018,13(12):603-605 |
| 大动脉粥样硬化型缺血性脑卒中患者SLCO1B1 基因
多态性分布--185 例分析 |
| Distribution of SLCO1B1 Gene Polymorphism in 185 Patients with Large ArteryAtherosclerosis-Subtype Ischemic Stroke |
| |
| DOI： |
| 中文关键词: 大动脉粥样硬化型缺血性脑卒中 SLCO1B1 基因 基因多态性 |
| 英文关键词: large artery atherosclerosis-subtype ischemic stroke SLCO1B1 gene gene polymorphism |
| 基金项目:国家自然科学基金资助项目（No.81501427）；武汉市科学技术局（应用基础研究计划）（No.2015060101010048） |
|
| 摘要点击次数: 3253 |
| 全文下载次数: 3777 |
| 中文摘要: |
| 目的：分析大动脉粥样硬化型缺血性脑卒中（LAA-IS）患者185 例中SLCO1B1 基因388A＞G 和
521T＞C多态性位点的分布。方法：LAA-IS患者185 例纳入研究，通过聚合酶链反应-荧光探针方法对其外
周血样本中SLCO1B1 基因的388G＞A和521T＞C位点进行检测并统计分析其基因分型分布。结果：根据
SLCO1B1 基因多态性分型，185 例LAA-IS 患者中SLCO1B1 基因388A＞G位点纯合野生型占8.6%，杂合突
变型占40.5%，纯合突变型占50.8%；521T＞C位点纯合野生型占77.8%，杂合突变型占21.0%，纯合突变型
占1.1%。结论：本组185 例LAA-IS患者中分布有较多的突变型SLCO1B1基因。 |
| 英文摘要: |
| To analyze the distribution of the SLCO1B1 gene 388A＞G and 521T＞C polymorphic
loci in 185 patients with large artery atherosclerosis-subtype ischemic stroke (LAA-IS). Methods: This study
recruited 185 LAA-IS patients as research subjects. The 388G>A and 521T>C loci of the SLCO1B1 gene in the
peripheral blood samples were detected by the polymerase chain reaction fluorescence probe method, and the
distribution of their genotyping was statistically analyzed. Results: According to the polymorphism of the
SLCO1B1 gene in the 185 LAA-IS patients, at the 388A>G site, homozygous wild type accounted for 8.6%,
heterozygous mutant type accounted for 40.5%, and homozygous mutant type accounted for 50.8%; at the 521T>
C site, homozygous wild type accounted for 77.8% , heterozygous mutant type accounted for 21.0% , and
homozygous mutant type accounted for 1.1%. Conclusion: Within the 185 cases in this study, there exists a
large distribution of mutant genotypes of the SLCO1B1 gene. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |