文章摘要
李晓鹏，赵鹏，钱进.血尿酸水平与初诊帕金森病轻度认知功能障碍相关性研究[J].神经损伤功能重建,2018,13(11):544-547
血尿酸水平与初诊帕金森病轻度认知功能障碍相关性研究
Study on Correlation between Serum Uric Acid Level and Mild Cognitive Dysfunction inNewly Diagnosed Parkinson's Disease
  
DOI：
中文关键词: 尿酸  帕金森病  轻度认知功能障碍  肌酐
英文关键词: uric acid  Parkinson's disease  mild cognitive impairment  creatinine
基金项目:
作者单位
李晓鹏1，赵鹏2，钱进2 1. 河南大学第一附属医院神经内科；2. 大连医科大学附属第一医院神经内科 
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中文摘要:
      目的：探讨血尿酸（UA）水平与初诊帕金森病（PD）患者轻度认知功能障碍的相关性。方法：选取在我 院第一次就诊并未进行任何抗PD治疗的80 例PD患者为PD组，随机选取同期我院体检的70 例体检者为对 照组。测定所有个体晨空腹血UA及肌酐（SCr）浓度；根据Hoehn-Yahr 分级（H-Y 分级）及帕金森病轻度认 知功能障碍（PD-MCI）诊断标准将PD组分为不同亚组。结果：2 组的血UA、蒙特利尔认知评估量表（Mo- CA）值比较差异有统计学意义（P<0.05）。PD-MCI亚组、PD-NCI 亚组的UA浓度低于对照组，PD-MCI亚组 的UA浓度低于PD-NCI亚组（均P<0.05）。对于男性或女性个体，PD-MCI亚组、PD-NCI亚组的UA浓度低于 对照组，PD-MCI亚组的UA浓度低于PD-NCI亚组（均P<0.05）。PD-MCI组中，PD早期亚组、中期亚组的Mo- CA值低于对照组，PD早期亚组MoCA值高于中期亚组（均P<0.05）；PD早期亚组、中期亚组UA浓度低于对照 组（均P<0.05）。UA浓度与PD患者MoCA量表的命名能力具有正相关性，与其余认知领域无明显相关性。 结论：血UA浓度的降低可能是PD的发生及其认知功能下降的机制之一。
英文摘要:
      To investigate the correlation between uric acid (UA) level and mild cognitive dysfunction in newly diagnosed patients with Parkinson’s disease (PD). Methods: Eighty patients diagnosed with PD who had not yet undergone any treatment were selected as the PD group. At the same time, 70 individuals receiving routine examinations were randomly selected as the control group. Fasted levels of serum UA and creatinine (SCr) were measured in all individuals. Patients in the PD group were subdivided according to Hoehn-Yahr stage (H-Y stage) and mild cognitive impairment (PD-MCI) diagnostic criteria. Results: There was a significant difference between the serum UA and Montreal Cognitive Assessment (MoCA) values of the two groups (P<0.05). The mild cognitive impairment (PD-MCI) subgroup and no cognitive impairment (PD-NCI) subgroup both showed lower serum UA levels compared to the control group, and the PD-MCI subgroup showed lower UA levels than the PD-NCI subgroup (all P<0.05). For either male or female individuals, UA levels in both PD-MCI and PD-NCI subgroups were lower than those in the control group, and UA levels in the PD-MCI subgroup were lower than those in the PD-NCI subgroup (all P<0.05). For PD-MCI patients, MoCA scores in the early and middle subgroups were lower than those in the control group, and MoCA scores in the early subgroup were higher than those in the middle subgroup (all P<0.05). UA levels in early and middle subgroups were lower than those in the control group (both P<0.05). There was a positive correlation between UA level and naming ability of MoCA in PD patients, and there was not a significant correlation with other cognitive fields. Conclusion: The decrease of UA level may be one of the mechanisms for the occurrence of PD and decline of cognitive function.
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