文章摘要
郭章宝 ，刘文华 ，许项前 ，欧阳方 ，唐坤 ，陈国华 ，唐荣华.入院血糖和发病到治疗时间对急性缺血性脑卒中 静脉溶栓预后的影响[J].神经损伤功能重建,2018,13(10):495-496
入院血糖和发病到治疗时间对急性缺血性脑卒中 静脉溶栓预后的影响
Analysis of Relationship between Blood Glucose at Admission and Time from Symptom Onsetto Treatment with Prognosis After Intravenous Thrombolysis in Acute Ischemic Stroke
  
DOI：
中文关键词: 急性缺血性脑卒中  rt-PA  静脉溶栓  影响因素
英文关键词: acute ischemic stroke  rt-PA  intravenous thrombolysis  influencing factors
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作者单位
郭章宝1 ，刘文华1 ，许项前2 ，欧阳方1 ，唐坤1 ，陈国华1 ，唐荣华3 1. 武汉市第一医院 神经内科；2. 湖北中医药大学；3. 华中科技大学同 济医学院附属同济 医院神经内科 
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中文摘要:
      目的：分析入院时血糖水平和发病到治疗的时间（ONT）对静脉溶栓治疗急性缺血性脑卒中预后的影 响。方法：回顾性分析我院通过卒中绿色通道收治的接受重组组织型纤溶酶原激活剂（rt-PA）静脉溶栓的急 性缺血性脑卒中107例患者的临床资料，按溶栓后24 h内美国国立卫生院脑卒中量表（NIHSS）评分变化值分 为有效组43例及无效组64例。比较2组的临床资料，并分析预后的影响的因素。结果：有效组90 d改良 Rankin量表（mRS）评分低于无效组（P＜0.05），有效组ONT和入院时血糖均低于无效组（P＜0.05）；多因素Logistic回归分析显示ONT（OR=0.992，P=0.025）和入院时血糖水平（OR=0.746，P=0.022）可能是影响预后的预 测因素。结论：尽早实施溶栓治疗和积极控制血糖水平可能是改善急性缺血性脑卒中患者预后的重要措施。
英文摘要:
      To investigate the correlation between blood glucoseat admission and time from symptom onset to treatment (ONT) with prognosis after intravenous thrombolytic therapy in patients with acute ischemic stroke. Methods: A total of 107 acute ischemic stroke patients who received intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) were retrospectively analyzed. They were divided into the effective group (43 cases) and the ineffective group (64 cases) according to National Institute of Health Stroke Scale (NIHSS) scores 24 h after intravenous thrombolytic therapy. Clinical data of the two groups were compared, and factors correlated with prognosis were analyzed. Results: The 90 d modified Rankin Scale (mRS) score of the effective group was lower than that of the ineffective group (P<0.05). The ONT and blood glucose at admission were both lower in the effective group than those in the ineffective group (P<0.05). Multiple Logistic regression analysis indicated ONT (OR=0.992, P=0.025) and blood glucose level at admission (OR=0.746, P=0.022) were factors correlated with prognosis． Conclusion: Implementing intravenous thrombolytic therapy as soon as possible and controlling blood sugar levels may be important steps in improving prognosis in patients with acute ischemic stroke
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