| 柳欣，冯美江，鲁翔.高龄老年体位性低血压患者并发神经退行性疾病的
临床研究[J].神经损伤功能重建,2018,13(8):395-398 |
| 高龄老年体位性低血压患者并发神经退行性疾病的
临床研究 |
| Clinical Study of the Changes of Postural Blood Pressure and Neurodegenerative Disease inElderly Patients with Hypertension |
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| DOI： |
| 中文关键词: 高龄 体位性低血压 神经退行性疾病 |
| 英文关键词: elderly orthostatic hypotension neurodegenerative diseases |
| 基金项目:北京力生心血管健
康 基 金 项 目（No.
BJLS-GYJJ201600
3） |
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| 摘要点击次数: 3754 |
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| 中文摘要: |
| 目的：了解80岁及以上高龄高血压患者体位性血压改变与神经退行性并发症的相关性。方法：对28
所三级甲等医院门诊和（或）住院的高血压患者开展联合问卷调查，年龄80～105岁。测量其坐位、卧位和直
立位3 min内血压值，并收集其病史、用药史及生活习惯等相关资料。结果：共1562例纳入本研究。分为体
位性低血压（OH）组387例，非体位性低血压（NOH）组1175例；OH患病率为24.8%（387例）。OH组较NOH
组易并发神经退行性疾病。Logistic回归分析结果显示，阿尔茨海默病及帕金森病与OH的患病率呈正相
关。结论：高龄高血压患者中OH患病率较高，且并发神经退行性疾病的高龄高血压患者易并发OH。 |
| 英文摘要: |
| To investigate the correlation between postural blood pressure changes and the
complications of neurodegenerative diseases in elderly patients over 80 years old who were diagnosed with
hypertension. Methods: A multicenter cross-sectional study was conducted among very old patients (≥80
years) with hypertension using questionnaire-based surveys at 28 Grade A tertiary Hospitals. A total of 1562
subjects aged between 80 and 105 were enrolled in this study. Blood pressures were measured in the sitting
position, the supine position and the upright position within 3 minutes of standing. Results: In a total of 1562
subjects, 387 patients were diagnosed with orthostatic hypotension (OH), the other 1175 patients were diagnosed
with non-orthostatic hypotension (NOH). The prevalence of OH was 24.8% . OH patients had higher rates
suffering from neurodegenerative diseases than NOH patients. The results of a logistic regression analysis
indicated that Alzheimer's disease and Parkinson's disease were both positively correlated with the prevalence of
OH. Conclusion: The prevalence of OH is high in elderly hypertensive patients over 80 years old. Elderly
hypertensive patients complicated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's
disease are likely to develop OH. |
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