文章摘要
阮清源，尹虹祥，魏衡.Hs-CRP水平与ABCD2评分对短暂性脑缺血发作 患者近期预后的评估价值[J].神经损伤功能重建,2018,13(7):331-334
Hs-CRP水平与ABCD2评分对短暂性脑缺血发作 患者近期预后的评估价值
Predictive Value of Hs-CRP Level and ABCD2 Score on Short-term Prognosis in Patients withTransient Ischemic Attack
  
DOI：
中文关键词: 短暂性脑缺血发作  急性脑梗死  超敏C反应蛋白  ABCD2评分
英文关键词: transient ischemic attack  acute cerebral infarction  high sensitivity C reactive protein  ABCD2 score
基金项目:
作者单位
阮清源，尹虹祥，魏衡 湖北省中西医结合 医院神经内科 
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中文摘要:
      目的：探讨超敏C反应蛋白（Hs-CRP）水平与ABCD2评分对短暂性脑缺血发作（TIA）患者近期预后的 评估价值。方法：选择TIA患者226例，依据发病后7 d 内有无进展急性脑梗死（ACI）分为ACI组27例和非 ACI 组 199 例。记录脑血管病危险因素、Hs-CRP 水平及 ABCD2 评分分值等。应用单因素及多因素分析 ACI组与非ACI组间脑血管病危险因素、Hs-CRP水平、ABCD2等差异性。应用受试者工作（ROC）曲线分析 ABCD2与Hs-CRP水平评估TIA 7 d内发生ACI风险的预测价值。结果：226例TIA患者中，进展为ACI 27 例，预后不良率为11.95%。单因素分析示，非ACI组与ACI组间高血压病、糖尿病、年龄＞65岁、持续时间≥ 30 min、发作次数≥3次、病程≥24 h、Hs-CRP水平、ABCD2评分差异均有统计学意义（均P＜0.05）。多因素 Logistic 回归分析示，高血压病、糖尿病、年龄＞65 岁、持续时间≥30 min、发作次数≥3 次、病程≥24 h、 Hs-CRP 水平及 ABCD2 评分均是 TIA 进展为 ACI 的独立危险因素。ROC 曲线分析示，ABCD2 评分及 Hs-CRP水平评估ACI发生的曲线下面积（AUC）分别为0.848、0.824。结论：ABCD2量表评分是一种简单、 有效的TIA预后的预测工具，且与Hs-CRP联合检测对TIA患者预后评估具有重要价值。
英文摘要:
      To assess the predictive value of high sensitivity C reactive protein (Hs-CRP) level and ABCD2 score in the short-term prognosis of patients with transient ischemic attack (TIA). Methods: Two hundred and twenty-six patients with TIA were involved in the study. Patients were divided based on the progression to acute cerebral infarction within 7 days of TIA into the ACI group (n=27) and non-ACI group (n= 199). Common cerebrovascular disease risk factors, Hs-CRP level, and ABCD2 score were recorded. Single factor and multi-factor analyses were used to assess the difference in risk factors of cerebrovascular disease, Hs-CRP level, ABCD2 score between the ACI group and non-ACI group. Receiver operating characteristic (ROC) curve analysis was used to investigate the value of ABCD2 score combined with Hs-CRP level in predicting the occurrence of ACI within 7 days of TIA. Results：Of the 226 patients, 27 developed ACI, yielding a 11.95% poor prognosis rate. Univariate analysis showed that there was a significant difference between the non-ACI group and ACI group in hypertension, diabetes, age >65 years, attack duration ≥30 min, attack frequency ≥3 times, course of disease ≥24 h, Hs-CRP level, and ABCD2 score (all P<0.05). Multi-factor logistic analyses showed that hypertension, diabetes, age >65 years, attack duration ≥30 min, attack frequency ≥3 times, course of disease ≥24 h, ABCD2 score, and Hs-CRP level were also independent risk factors for the development of ACI after TIA. ROC curve analysis revealed that in predicting ACI, the ABCD2 score and Hs-CRP level showed an area under the curve (AUC) of 0.848 and 0.824, respectively. Conclusion: ABCD2 score is a simple and effective tool in predicting TIA prognosis, and Hs-CRP level combined with ABCD2 score offers significant predictive value in determining TIA prognosis.
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