| 杨添淞
，杨燕
，王德龙
，王玉琳
，郭静
，石天宇
，屈媛媛
，王月
，孙维伯
，孙忠人.电针干预对慢性疲劳综合征大鼠海马和下丘脑区
p65及COX-2蛋白表达的影响[J].神经损伤功能重建,2018,13(7):325-327 |
| 电针干预对慢性疲劳综合征大鼠海马和下丘脑区
p65及COX-2蛋白表达的影响 |
| Effects of Scalp Electroacupuncture on Expression of p65 and COX-2 Protein in Hippocampusand Hypothalamus of Rats with Chronic Fatigue Syndrome |
| |
| DOI： |
| 中文关键词: 慢性疲劳综合征 NF-κB p65 COX-2 |
| 英文关键词: chronic fatigue syndrome NF-κB p65 COX-2 |
| 基金项目:国家自然科学基金
（No. 81704170，814
73761）；教育部博
士点基金（No. 2012
2327110007）；黑龙
江省中医管理局课
题（No.ZHY
16-003） |
|
| 摘要点击次数: 3507 |
| 全文下载次数: 4203 |
| 中文摘要: |
| 目的：探讨电针干预对慢性疲劳综合征（CFS）大鼠海马和下丘脑区NF-κB p65和COX-2蛋白表达的
影响。方法：清洁级SD雄性大鼠36只，随机将大鼠分为正常组、模型组、治疗组各12只，建立CFS动物模
型，治疗组选择百会、情感 1 区、感觉区给予电针治疗，应用免疫组化方法，检测各组大鼠海马、下丘脑区
NF-κB p65及COX-2表达的变化情况。结果：模型组大鼠海马和下丘脑区可见 NF-κB p65、COX-2 蛋白阳
性表达显著增加，与正常组比较有显著性差异（P＜0.01）；治疗组大鼠海马和下丘脑的 NF-κB p65 阳性细
胞表达明显减少，与模型组比较有显著性差异（P＜0.01）。结论：针刺治疗能降低CFS大鼠海马与下丘脑
中NF-κB p65、COX-2蛋白表达。 |
| 英文摘要: |
| To investigate the effects of scalp electroacupuncture on the expression of NF-κB p65
and COX-2 protein in the hippocampus and hypothalamus of rats with chronic fatigue syndrome (CFS).
Methods: Thirty-six pathogen-free male SD rats were randomly divided into the normal group, model group,
and treatment group with 12 rats per group. The CFS animal model was established. The treatment group was
given acupuncture therapy to the Baihui, emotional zone 1, and sensory zone. Immunohistochemistry was
employed to examine the variation in expression of NF-κB p65 and COX-2 in the hippocampus and
of rats in each group. Results: Compared with that of the normal group, the hippocampus and hypothalamus of
rats in the model group showed significantly increased positive expression of NF-κB p65 and COX-2 protein (P<
0.01). Compared with that of the model group, the hippocampus and hypothalamus of rats in the treatment group
displayed significantly reduced expression of NF-κB p65 positive cells (P<0.01). Conclusion: Acupuncture can
reduce the expression of NF-κB p65 and COX-2 protein in the hippocampus and hypothalamus of CFS rats. |
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