| 涂宇
，巩萱
，卓文燕
，陈欢
，林晶
，范玉华.不同病因下急性脑梗死合并缺血性脑白质病变
与血同型半胱氨酸水平的相关性探讨[J].神经损伤功能重建,2018,13(5):225-227 |
| 不同病因下急性脑梗死合并缺血性脑白质病变
与血同型半胱氨酸水平的相关性探讨 |
| Study on the Correlation Between ACI Combining with Ischemic Leukodystrophy andHomocysteine Level Under Different Disease Causes |
| |
| DOI： |
| 中文关键词: 缺血性脑白质病变 脑梗死 同型半胱氨酸 改良TOAST分型 |
| 英文关键词: ischemic leukodystrophy cerebral infarction blood homocysteine modified TOAST classification |
| 基金项目:国家自然科学基金
（No.81000514）；广
东省自然科学基金
（No.S20130100158
40） |
|
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| 中文摘要: |
| 目的：探讨血同型半胱氨酸（Hcy）水平与急性脑梗死（ACI）合并缺血性脑白质病变（WMIL）在不同病
因下的相关性。方法：选择 ACI、WMIL 患者 280 例，分为单纯动脉粥样硬化血栓型脑梗死（AT）组、单纯
WMIL组、（AT+WMIL）组及（小动脉闭塞卒中+WMIL）（SAO+WMIL）组各70例，测定其血Hcy水平，组间
互相比较。结果：（AT+WMIL）组、（SAO+WMIL）组的Hcy水平高于单纯WMIL组（P＜0.05，P＜0.01）。Logistic 回归分析结果显示年龄、TG 对 ACI 合并 WMIL 患者的影响具有统计学意义（P＜0.05），同时 Hcy 对
ACI合并WMIL患者的影响更具统计学意义（P＜0.01）。结论：Hcy水平升高与ACI合并WMIL的发生密切
相关，但其与病因无相关性 |
| 英文摘要: |
| To discuss the correlation between homocysteine (Hcy) level and acute cerebral
infarction (ACI) combining with white matter ischemic lesion (WMIL) under different disease causes.
Methods: A total of 280 patients with ACI combined with WMIL verified by CT and MRI were recruited to this
study. Patients were divided into the atherosclerosis thrombotic cerebral infarction only group (AT group), WMIL
only group (WMIL group), (AT+WMIL) group, and (SAO+WMIL) group, with 70 patients per group. The level
of Hcy was measured for comparisons among groups. Results: The Hcy level of the (AT+WMIL) group and
(SAO +WMIL) group was higher than that of the WMIL group (P<0.05, P<0.05). Logistic regression analysis
indicated that age and TG are statistically significant factors in ACI patients with WMIL (P<0.05); meanwhile,
Hcy showed more statistical significance in these patients (P<0.01). Conclusion: Elevated Hcy level is closely
related to ACI with WMIL, but it has no correlation with the etiology of ACI with WMIL. |
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