| 李颖慧
，张林山
，伍国锋
，任思颖
，李军
，王丽琨
，杨林.家兔脑出血模型头颅CT值变化规律初步探讨[J].神经损伤功能重建,2018,13(5):217-220 |
| 家兔脑出血模型头颅CT值变化规律初步探讨 |
| Preliminary Study on Variation Pattern of CT Values in Rabbits with Cerebral Hemorrhage |
| |
| DOI： |
| 中文关键词: 脑出血 CT 混合征 家兔 |
| 英文关键词: intracerebral hemorrhage CT blend sign rabbit |
| 基金项目:国家自然科学基金
（No.81460185/
H906）；
贵州省科学技术基
金（[ 2013）2043]；
贵州省高血压性脑
出血微创诊疗科技
创新人才团队基金
[黔科合人才团队
（2014）2040]；
贵阳市科技计划项
目 ( 筑 科 合 同
[20161001]51 号 ）
及（筑科合同[2017]
5-1号） |
|
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| 中文摘要: |
| 目的：通过立体定向技术注射家兔自体动脉血到达脑基底节区的方法，构建家兔脑出血模型，分析不
同时间段注射血液后头颅CT值的演变规律，探讨脑出血后头颅CT混合征形成的可能机制。方法：健康家
兔70只，根据注入脑组织血液成分的不同分为全血组（50只）、血浆组（10 只）和血清组（10 只）；对于全血
组，根据注血间隔时间的不同又分为 5 个亚组，分别为 A 亚组（间隔 1 h）、B 亚组（间隔 2 h）、C 亚组（间隔
3 h）、D亚组（间隔4 h）、E亚组（间隔5 h），每组10只，首次注射自体动脉血形成血肿后分别在不同时间段内
再次注射相同成分的血液到血肿周边形成二次血肿；对于血清组和血浆组，于注射全血形成血肿后同时间
段内向血肿周边或对侧分别注射自体血血清或血浆，造模完成后立即行头颅CT，记录家兔头颅CT不同区
域的CT值，对比注射不同血液成分CT值的变化和同一血液成分间隔不同时间CT值的变化规律。结果：全
血组经不同时间段向颅内注血可形成高低不同密度的血肿病灶，其低密度部位CT值高于脑组织与脑脊液，
类似混合征表现；血清和血浆组亦可形成高低密度，但低密度部位与脑脊液CT值相近，不易区分，不符合混
合征征象。结论：二次出血可能是脑出血头颅CT混合征的形成原因，而低密度区可能是首发出血，高密度
区则可能是新发出血。 |
| 英文摘要: |
| To establish a rabbit model of intracerebral hemorrhage by injecting autologous arterial
blood into the basal ganglia region of rabbits by stereotactic technique, then analyze the evolution of CT values
after injection of blood at different time periods in order to explore the possible mechanism of the formation of
blend sign. Methods: Seventy healthy rabbits were divided into whole blood group (n=50), plasma group (n=
10), and serum group (n=10) according to the different blood components injected into the brain. The whole
blood group was divided into 5 subgroups with 10 rabbits per subgroup according to time interval between
injections: subgroup A (1 h gap), subgroup B (2 h gap), subgroup C (3 h gap), subgroup D (4 h gap), and
subgroup E (5 h gap). After the first injection of autologous arterial blood to form a hematoma, the same
component of blood was injected again at different intervals into the periphery of the hematoma to form a
secondary hematoma; for rabbits in the serum group and plasma group, after hematoma was formed by injection
of whole blood, within the same period of time, serum or plasma was injected at positions contralateral or
ipsilateral to the first hematoma. Head CT scan was performed immediately following generation of model, and
CT value of different cerebral regions was recorded. The CT value of groups injected with different blood
components was compared, and the CT value variation pattern between groups injected with the same
components at different time intervals was assessed. Results: In the whole blood group, injection of blood at
different time intervals resulted in hematoma lesions of different densities. The CT value at the low-density site
was higher than that of brain tissue and cerebrospinal fluid and was similar to the blend sign. The high and low
densities were also formed in the serum and plasma groups, but the low-density sites showed similar CT values
as that of cerebrospinal fluid; it was not easily distinguishable and did not meet the criteria of blend sign.
Conclusion: Secondary hemorrhage may be the cause of brain CT blend sign in intracerebral hemorrhage.
Low-density areas may indicate initial bleeding while high-density areas may be secondary bleeding |
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