| 葛晓敏，杜磊，马建华.影响中青年急性缺血性卒中脑血管狭窄的
危险因素研究[J].神经损伤功能重建,2018,13(2):62-65 |
| 影响中青年急性缺血性卒中脑血管狭窄的
危险因素研究 |
| The Risk Factors for Acute Ischemic Stroke in Young and Middle-aged Patients with Cerebro⁃Vascular Stenosis |
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| DOI： |
| 中文关键词: 中青年 缺血性卒中 头颈CT血管成像 数字减影血管造影 危险因素 |
| 英文关键词: middle-age and young ischemic stroke head and neck CT angiography,digital subtraction risk
factor |
| 基金项目:国家自然科学基金
（No. 81060097） |
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| 中文摘要: |
| 目的：探讨影响中青年急性缺血性卒中脑血管狭窄的危险因素。方法：回顾性收集中青年急性缺血性
卒中临床资料130例，根据检查结果分为血管狭窄组64例和无血管狭窄组66例，并根据血管狭窄程度进一
步分为轻度狭窄亚组16例，中重度狭窄亚组17例，闭塞亚组31例。收集甘油三酯（TG）、低密度脂蛋白胆固
醇（LDL-C）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、高血
压史、血糖病史、体质指数（BMI）等资料，分析血脂变量与血管狭窄程度的关系及血管狭窄的危险因素。结
果：2组间高血压病史≥10年、TC、TC/HDL-C比较有统计学差异（P<0.05）；TC、TC/HDL-C与血管狭窄程度
呈正相关（P<0.01）；轻度、中重度狭窄亚组TC、TC/HDL-C低于闭塞亚组（P<0.05）；高血压病史≥10年、TC/
HDL-C可能是新疆中青年急性缺血性卒中血管狭窄的独立危险因素（P<0.05）。结论：TC、TC/HDL-C与中
青年急性缺血性卒中血管狭窄水平密切相关；血清TC/HDL-C和高血压病史≥10年可能可作为预测独立中
青年急性缺血性卒中血管狭窄的危险因素。 |
| 英文摘要: |
| To study the risk factors for acute ischemic stroke in middle-aged and young patients
with cerebrovascular stenosis in Xinjiang. Methods: Clinical data of 130 middle-aged and young patients with
acute ischemic stroke were collected. Cases were divided into the cerebrovascular stenosis group (n=64) and the
no cerebrovascular stenosis group (n=66). Stenosis group was further divided into mild stenosis group (n=16),
moderately severe stenosis group (n=17), and occlusion group (n=31). Data was collected on patient serum levels
of triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high density lipoprotein
cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, as well as history of high blood pressure, history
of diabetes, and BMI. Data was analyzed for correlation between serum lipid index and degree of cerebrovascular stenosis, and analysis of risk factors for cerebrovascular stenosis was performed. Results: Hypertension of ≥
10 years, TC, and TC/HDL-C were significantly different between the cerebrovascular stenosis group and no
cerebrovascular stenosis group (P<0.05). TC and TC/HDL-C were positively correlated with cerebrovascular stenosis degree (P<0.01). Serum TC level and TC/HDL-C were significantly lower in the moderate and mild stenosis groups than in the occlusion group (P<0.05). Hypertension of ≥10 years and TC/HDL-C were independent
risk factors for middle-aged and young patients of ischemic stroke with cerebrovascular stenosis (P<0.05). Con⁃
clusion: Serum TC and TC/HDL-C were closely related with degree of cerebrovascular stenosis in middle-aged
and young patients of acute ischemic stroke in Xinjiang. Hypertension of ≥10 years and TC/HDL-C can thus be
considered risk factors for middle-aged and young acute ischemic stroke with cerebrovascular stenosis． |
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