文章摘要
董发达 ，马晓虎 ，田冰锋.ADRB2基因多态性与aSAH迟发性脑血管痉挛的 关联性研究[J].神经损伤功能重建,2018,13(1):6-8
ADRB2基因多态性与aSAH迟发性脑血管痉挛的 关联性研究
Association between Polymorphism of Beta-2 Adrenergic Receptor and Delayed Cerebral Va⁃sospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
  
DOI：
中文关键词: β2肾上腺素能受体  动脉瘤性蛛网膜下腔出血  迟发性脑血管痉挛  基因多态性
英文关键词: Beta-2 adrenergic receptor  aneurysmal subarachnoid hemorrhage  delayed cerebral vasospasm  gene polymorphism
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作者单位
董发达1 ，马晓虎1 ，田冰锋2 1. 咸阳市第一人民 医院神经外科 2.汉中市中心医院 神经外科 
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中文摘要:
      目的：探讨中国北方汉族人群中，动脉瘤性蛛网膜下腔出血（aSAH）后迟发性脑血管痉挛（DCVS）与 β2肾上腺素能受体（ADRB2）基因多态性的关系。方法：aSAH患者206例纳入研究，按照是否合并DCVS分 为DCVS组128例和无DCVS组78例，采用聚合酶链反应-限制性片段长度多态性法检测ADRB2基因A46G 位点和C79G位点多态性。结果：单因素分析结果显示ADRB2基因A46G位点等位基因模型（A vs. G）和显 性基因模型（A/A vs. A/G + G/G）均与DCVS发生相关；多因素Logistics回归分析结果显示ADRB2基因+46 位点等位基因 G 和基因型（A/G + G/G）与 aSAH 患者发生 DCVS 的危险因素（OR=1.414，95%CI：1.142~ 4.817，P=0.039；OR=1.337，95%CI：1.076~3.191，P=0.045）；C79G位点各基因模型与DCVS相关性均无统计 学意义。结论：对于中国北方汉族aSAH患者，ADRB2基因A46G位点多态性与DCVS发生相关。
英文摘要:
      To investigate the genetic association between Beta-2 Adrenergic Receptor (ADRB2) gene polymorphism and delayed cerebral vasospasm (DCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH) in the Han descent population in North of China. Methods: Two hundred and six aSAH patients were recruited. According to whether DCVS occurred, cases were divided into the DCVS group (n=128) and the non-DCVS group (n=78). Polymerase chain reaction-restriction fragment length polymorphism combined with DNA direct sequencing technique were used to determine the polymorphism of the ADRB2 gene. Results: Univariate analysis showed independent association between allele model (A vs. G) and the dominant model (A/A vs. A/G + G/G) of ADRB2 gene A46G polymorphism and DCVS. Multivariate Logistic regression analysis showed that ADRB2 gene +46 position allele G and genotype (A/G + G/G) were risk factors of DCVS for aSAH patients (OR=1.414, 95%CI: 1.142~4.817, P=0.039; OR=1.337, 95%CI: 1.076~3.191, P=0.045). However, there was no significant difference in the frequencies of genotype and allele of C79G polymorphism between the DCVS group and the non-DCVS group. Conclusion: For aSAH patients in the Han descent population in the North of China, A46G polymorphism ofADRB2 gene may closely related to DCVS.
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