| 严子昂，田其，李明昌.星形胶质细胞在睡眠剥夺引发认知功能障碍中的作用机制研究进展[J].神经损伤功能重建,2024,(知网首发): |
| 星形胶质细胞在睡眠剥夺引发认知功能障碍中的作用机制研究进展 |
| Mechanisms of Astrocytes in Sleep Deprivation Triggered Cognitive Impairment: A Review |
| |
| DOI： |
| 中文关键词: 星形胶质细胞 睡眠剥夺 认知功能障碍 β-淀粉样蛋白 α7烟碱型乙酰胆碱受体 |
| 英文关键词: astrocytes sleep deprivation cognitive impairment amyloid β-protein α7 nicotinic acetylcholine
receptors |
| 基金项目:国家自然科学基金
项 目（BAP1 介 导
H2B去泛素化抑制
System Xc-在蛛网
膜下腔出血神经元
铁死亡中的作用和
机制研究，No. 821
72173） |
|
| 摘要点击次数: 172 |
| 全文下载次数: 136 |
| 中文摘要: |
| 由于不良生活方式、疾病影响或环境等多种诱因导致的睡眠时长不足称为睡眠剥夺，其会直接导致
认知功能受损。研究发现睡眠剥夺对星形胶质细胞的影响可能是导致认知功能障碍的关键节点。星形胶
质细胞发挥作用的机制至今尚未完全明确，可能通过参与突触可塑性、β-淀粉样蛋白沉积、兴奋性神经递质
蓄积、氧化应激和免疫炎症等多种途径。本综述回顾了近十年与星形胶质细胞、睡眠剥夺和认知功能障碍
相关的研究，归纳整理了相关的影响因素和机制通路，还梳理了发病机制的互作关系并探讨了潜在的治疗
策略。以期提供一个更全面的视角，理解星形胶质细胞在睡眠剥夺中的作用，并推动相关领域的研究进一
步发展，为开发新的治疗方法和干预措施提供理论基础。 |
| 英文摘要: |
| Insufficient sleep duration, referred to as sleep deprivation, can be caused by various triggers such as
poor lifestyle habits, disease, or environmental factors, which can directly lead to impaired cognitive function.
Research suggests that the impact of sleep deprivation on astrocytes may be a key node leading to cognitive
dysfunction. The mechanisms by which astrocytes exert their effects has not yet been fully elucidated; however,
they may involve multiple pathways including participation in synaptic plasticity, β-amyloid deposition,
accumulation of excitatory neurotransmitters, oxidative stress, and immune inflammation. This review
summarizes researches over the past decade related to astrocytes, sleep deprivation, and cognitive impairments.
It consolidates the relevant influencing factors and mechanistic pathways, outlines the interactive relationships
of the pathogenic mechanisms, and explores potential therapeutic strategies. The aim is to provide a more
comprehensive perspective on the role of astrocytes in sleep deprivation, promoting further development in
related research fields and providing a theoretical basis for the development of new treatment methods and
intervention measures. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |