文章摘要
郭啸鸣 ，缪玲仲 ，陆珍辉 ，朱向阳.前庭康复增强度洛西汀治疗持续性姿势-知觉性头晕的疗效[J].神经损伤功能重建,2023,(知网首发):
前庭康复增强度洛西汀治疗持续性姿势-知觉性头晕的疗效
Efficacy of Vestibular Rehabilitation Enhanced Duloxetine in Treatment of PersistentPostural-Perceptual DizzinessEfficacy of Vestibular Rehabilitation Enhanced Duloxetine in Treatment of PersistentPostural-Perceptual Dizziness
  
DOI：
中文关键词: 前庭康复  持续性姿势-知觉性头晕  焦虑  抑郁  睡眠障碍
英文关键词: vestibular rehabilitation  persistent postural-perceptual dizziness  anxiety  depression  sleep disturbance
基金项目:江苏省卫生健康委 科研项目（No. H20 19057）；南通市卫 健委青年项目（No. QA2019015）
作者单位
郭啸鸣1 ，缪玲仲2 ，陆珍辉1 ，朱向阳1 1. 南通大学第二附 属医院神经内科 2. 南通市市级机关 门诊部1. 南通大学第二附 属医院神经内科 2. 南通市市级机关 门诊部 
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中文摘要:
      目的：评估增加前庭康复是否能提高度洛西汀治疗持续性姿势-知觉性头晕（PPPD）的疗效。方法： 120 例 PPPD 患者，按治疗方法不同分为研究组和对照组，2 组患者均于早晨服用度洛西汀，起始剂量为 30 mg/d，在1周后调整至60 mg/d。研究组在服药的同时即开始进行前庭康复。治疗持续8周。比较2组 在治疗前、治疗4、8周时的眩晕残障量表（DHI）、医院焦虑抑郁量表（HADS）、匹兹堡睡眠质量指数量表 （PSQI）评分及不良反应。结果：治疗8周后，2组的DHI、HADS-A、HADS-D和PSQI评分均显著下降（P＜ 0.05）。与对照组相比，研究组在第 8 周的 DHI、HADS-A、HADS-D 和 PSQI 评分均显著低于对照组（P＜ 0.05）。结论：前庭康复可显著提高度洛西汀治疗PPPD的疗效。
英文摘要:
      To assess whether the addition of vestibular rehabilitation (VR) could significantly improve the efficacy of Duloxetine in treating persistent postural-perceptual dizziness (PPPD). Methods: A total of 120 patients with PPPD were divided into study group and control group according to treatment method. Both groups were given Duloxetine in the morning with a starting dose of 30 mg/day and an adjustment to 60 mg/day after 1 week. The study group was simultaneously given VR. Treatment was continued for 8 weeks. The Dizziness Handicap Inventory (DHI), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index scale (PSQI) scores, and adverse reactions were compared between the two groups before and at 4 and 8 weeks of treatment. Results: After 8 weeks of treatment, the HADS-A, HADS-D, and PSQI scores were significantly decreased in both groups (P<0.05). Compared to the control group, the study group had significantly lower HADS-A, HADS-D, and PSQI scores at week 8 (P<0.05). Conclusion: The addition of VR could significantly improve the efficacy of Duloxetine in treating PPPD.
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