| 李小竟
，李心乐
，卢秀煦
，赖鸿鹄
，肖海伦
，孙炜
，吕光耀.基于孟德尔随机化研究阿尔兹海默病领域热点的可视化分析[J].神经损伤功能重建,2025,(知网首发): |
| 基于孟德尔随机化研究阿尔兹海默病领域热点的可视化分析 |
| Visual Analysis of Reasearch Hotspots in the Field of Alzheimer's Disease Based on Mende⁃lian Randomization |
| |
| DOI： |
| 中文关键词: 阿尔兹海默病 孟德尔随机化 可视化分析 生物标志物 |
| 英文关键词: Alzheimer's disease Mendelian randomization visual analysis biomarker |
| 基金项目:国家中医药管理局
第四批中医临床（基
础）优秀人才项目
（J20184832009）；
深圳市“医疗卫生
三 名 工 程 ”项 目
（SZZYSM2021060
09） |
|
| 摘要点击次数: 328 |
| 全文下载次数: 323 |
| 中文摘要: |
| 目的：通过孟德尔随机化研究探索阿尔兹海默病领域的热点话题及发展趋势。方法：检索 Web of
Science核心合集数据库应用孟德尔随机化研究阿尔兹海默病的相关英文文献，检索时间为建库至2024年3
月，并用CiteSpace 6.2.R4对发表文献的作者、国家、机构、文献共被引、关键词共现、关键词聚类情况进行可
视化分析并绘制知识图谱。利用智慧芽全球新药情报数据库查询与阿尔兹海默病相关的生物标志物的药
物研发情况。结果：去重后共纳入347篇英文文献，年度发文量呈现上升趋势。英国学者Ben-shlomo Yoav
中介中心性最高；发文量前3位的国家是中国、美国和英国，中介中心性排名前3位的国家依次是波兰、法国
和加拿大，中国发文量最高，但仅与美国和荷兰存在合作；发文量前3位的机构是伦敦大学、哈佛大学和复
旦大学；关键词聚类图中，“#0 risk factors（危险因素）”与AD的生物标志物关系最紧密，其中APP和TAU是
更具潜力的药物靶点。结论：孟德尔随机化研究阿尔兹海默病主要在中国、英国和美国开展。主要热点是
研究AD发病的危险因素，如脑脊液中淀粉样蛋白等，且相关研究发现APP和TAU是更为重要的生物标志
物及药物靶点。 |
| 英文摘要: |
| To explore the hot topics and development trends in the field of Alzheimer's disease
(AD) through Mendelian randomization (MR) studies. Methods: Relevant English literature on MR studies of
AD was retrieved from the Web of Science Core Collection database, spanning from the inception of the
database to March 2024. CiteSpace 6.2.R4 was utilized for visual analysis of authors, countries, institutions,
co-citation of documents, co-occurrence of keywords, and keyword clustering, and a knowledge map was
constructed. Additionally, the PatSnap Global New Drug Intelligence Database was consulted to investigate the
drug development status of biomarkers related to AD. Results: A total of 347 English articles were included
after deduplication, with an increasing trend in annual publication volume. British scholar Ben-shlomo Yoav had
the highest betweenness centrality. The top three countries in terms of publication volume were China, the
United States, and the United Kingdom, while the top three countries in betweenness centrality were Poland,
France, and Canada. China had the highest publication volume but only collaborated with the United States and
the Netherlands. The top three institutions were University College London, Harvard University, and Fudan
University. In the keyword clustering map, "#0 risk factors" was most closely related to AD biomarkers, with
amyloid precursor protein (APP) and tau (TAU) emerging as more promising drug targets. Conclusion: MR
studies on AD are mainly conducted in China, the UK, and the US. The primary research focus is on risk factors
for AD onset, such as amyloid protein in cerebrospinal fluid. Related studies have identified APP and TAU as
more important biomarkers and drug targets. |
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